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Protein Engineering of Delta-endotoxin by Domain Shuffling: Generation of Novel Toxins with Enhanced Toxicity / Broader Specificity
Ananda Kumar Polumetla
Protein Engineering of Delta-endotoxin by Domain Shuffling: Generation of Novel Toxins with Enhanced Toxicity / Broader Specificity
Ananda Kumar Polumetla
The structural similarity of all members of the family of three-domain Bt toxins and the separate roles of the domains in the processes of receptor binding and channel formation suggested that combining domains from different proteins could generate active toxins with novel specificities. Protein engineering not only reveals the mechanism by which endotoxins work, but it can generate toxins with enhanced toxicity/introduce a specific activity into a toxin that does not possess it. Evolution of resistance to more than one toxin is associated with the alteration of a common binding site in several insect species. Thus, knowledge of which toxins share binding sites can help in choosing appropriate sets of toxins for delaying resistance.
Media | Books Paperback Book (Book with soft cover and glued back) |
Released | October 26, 2012 |
ISBN13 | 9783659171130 |
Publishers | LAP LAMBERT Academic Publishing |
Pages | 380 |
Dimensions | 150 × 21 × 225 mm · 584 g |
Language | German |
See all of Ananda Kumar Polumetla ( e.g. Paperback Book )