Protein Engineering of Delta-endotoxin by Domain Shuffling: Generation of Novel Toxins with Enhanced Toxicity / Broader Specificity - Ananda Kumar Polumetla - Books - LAP LAMBERT Academic Publishing - 9783659171130 - October 26, 2012
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Protein Engineering of Delta-endotoxin by Domain Shuffling: Generation of Novel Toxins with Enhanced Toxicity / Broader Specificity

Ananda Kumar Polumetla

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Protein Engineering of Delta-endotoxin by Domain Shuffling: Generation of Novel Toxins with Enhanced Toxicity / Broader Specificity

The structural similarity of all members of the family of three-domain Bt toxins and the separate roles of the domains in the processes of receptor binding and channel formation suggested that combining domains from different proteins could generate active toxins with novel specificities. Protein engineering not only reveals the mechanism by which endotoxins work, but it can generate toxins with enhanced toxicity/introduce a specific activity into a toxin that does not possess it. Evolution of resistance to more than one toxin is associated with the alteration of a common binding site in several insect species. Thus, knowledge of which toxins share binding sites can help in choosing appropriate sets of toxins for delaying resistance.

Media Books     Paperback Book   (Book with soft cover and glued back)
Released October 26, 2012
ISBN13 9783659171130
Publishers LAP LAMBERT Academic Publishing
Pages 380
Dimensions 150 × 21 × 225 mm   ·   584 g
Language German