Synthetic Studies on N-aryl-gamma-lactams: Selective Functional Group Transformations and Development of Synthetic Routes to N-aryl-pyrroles and Pyrroloquinolines

Due to growing number of bacterial strains acquiring resistance to the current arsenal of chemotherapeutic drugs, the search for novel anti bacterial agents continue to be a major area of research in many fronts. During the last decade,various groups have directed their efforts to synthesize various bioactive gamma-lactams. Modification of lactam ring has been playing a vital role in determining the bio-activities of these derivatives and so exploration of a novel methodology in a simple way is a pivotal focal point of research activity in bioorganic chemistry. Progress in the art of organic synthesis in the last decades has been achieved by marked advances in chemo-,regio-and stereoselective functional group transformations by using classical and newly developed reagents. The book entitled "Synthetic Studies on N-aryl- gamma-lactams" is an embodiment of research aimed at developing simple methodologies for selective functional group transformations of N-aryl- gamma-lactams and an effort towards the development of new synthetic strategies for conversion of N-aryl- gamma-lactams to substituted pyrrole and pyrroloquinoline derivatives.